The Pore-Forming Toxin Listeriolysin O Is Degraded by Neutrophil Metalloproteinase-8 and Fails To Mediate Listeria monocytogenes Intracellular Survival in Neutrophils

The pore-forming toxin listeriolysin O (LLO) is a major virulence factor secreted by the facultative intracellular pathogen Listeria monocytogenes. This toxin facilitates L. monocytogenes intracellular survival in macrophages and diverse nonphagocytic cells by disrupting the internalization vesicle,...

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Bibliographic Details
Main Authors: Arnett, Eusondia, Vadia, Stephen, Nackerman, Colleen C., Oghumu, Steve, Satoskar, Abhay R., McLeish, Kenneth R., Uriarte, Silvia M., Seveau, Stephanie
Format: Artigo
Language:Inglês
Published: AAI 2014
Subjects:
Infectious Disease and Host Response
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876913/
https://ncbi.nlm.nih.gov/pubmed/24319266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301302
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