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Parallel Synthesis of 1,6-Disubstituted-1,2,4-Triazin-3-Ones on Solid-Phase

A parallel solid-phase synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones from MBHA resin is described. The reduction of resin-bound nitrosamino acids provides hydrazines efficiently without affecting the amide bond. The trityl protected hydrazine is then reduced with borane, and cyclized with 1,1-...

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Détails bibliographiques
Auteurs principaux: Hu, Miao, Huang, Wei, Giulianotti, Marc A., Houghten, Richard A., Yu, Yongping
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875618/
https://ncbi.nlm.nih.gov/pubmed/23750635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co400064d
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