Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase

High levels of striatal-enriched protein tyrosine phosphatase (STEP) activity are observed in a number of neuropsychiatric disorders such as Alzheimer’s disease. Over-expression of STEP results in the dephosphorylation and inactivation of many key neuronal signaling molecules, including ionotropic g...

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Huvudupphovsmän: Baguley, Tyler D., Xu, Hai-Chao, Chatterjee, Manavi, Nairn, Angus C., Lombroso, Paul J., Ellman, Jonathan A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875168/
https://ncbi.nlm.nih.gov/pubmed/24083656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401037h
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