G protein-gated inwardly rectifying potassium (K(IR)3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites

BACKGROUND AND PURPOSE: Oxycodone and morphine are μ-opioid receptor agonists prescribed to control moderate-to-severe pain. Previous studies suggested that these opioids exhibit different analgesic profiles. We hypothesized that distinct mechanisms mediate the differential effects of these two opio...

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Bibliographic Details
Main Authors: Nakamura, Atsushi, Fujita, Masahide, Ono, Hiroko, Hongo, Yoshie, Kanbara, Tomoe, Ogawa, Koichi, Morioka, Yasuhide, Nishiyori, Atsushi, Shibasaki, Masahiro, Mori, Tomohisa, Suzuki, Tsutomu, Sakaguchi, Gaku, Kato, Akira, Hasegawa, Minoru
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874711/
https://ncbi.nlm.nih.gov/pubmed/24117458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12441
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