Osteoprotegerin (OPG) activates integrin, focal adhesion kinase (FAK), and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis

BACKGROUND: Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligan...

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Detalhes bibliográficos
Main Authors: Lane, Denis, Matte, Isabelle, Laplante, Claude, Garde-Granger, Perrine, Rancourt, Claudine, Piché, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874685/
https://ncbi.nlm.nih.gov/pubmed/24267510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-6-82
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