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The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...

詳細記述

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書誌詳細
主要な著者: Steiner, Michel A., Sciarretta, Carla, Pasquali, Anne, Jenck, Francois
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874552/
https://ncbi.nlm.nih.gov/pubmed/24416020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00165
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