Site Specific Activation of AKT Protects Cells from Death Induced by Glucose Deprivation

The serine/threonine kinase AKT is a key mediator of cancer cell survival. We demonstrate that transient glucose deprivation modestly induces AKT phosphorylation at both Thr308 and Ser473. In contrast, prolonged glucose deprivation induces selective AKTThr308 phosphorylation and phosphorylation of a...

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Autori principali: Gao, Meng, Liang, Jiyong, Lu, Yiling, Guo, Huifang, German, Peter, Bai, Shanshan, Jonasch, Eric, Yang, Xingsheng, Mills, Gordon B., Ding, Zhiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874430/
https://ncbi.nlm.nih.gov/pubmed/23396361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.2
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