UV light-induced DNA lesions cause dissociation of yeast RNA polymerases-I and establishment of a specialized chromatin structure at rRNA genes

The cytotoxicity of UV light-induced DNA lesions results from their interference with transcription and replication. DNA lesions arrest elongating RNA polymerases, an event that triggers transcription-coupled nucleotide excision repair. Since arrested RNA polymerases reduce the accessibility of repa...

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Bibliographic Details
Main Authors: Tremblay, Maxime, Charton, Romain, Wittner, Manuel, Levasseur, Geneviève, Griesenbeck, Joachim, Conconi, Antonio
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874186/
https://ncbi.nlm.nih.gov/pubmed/24097442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt871
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