Nucleosome positioning and kinetics near transcription-start-site barriers are controlled by interplay between active remodeling and DNA sequence

We investigate how DNA sequence, ATP-dependent chromatin remodeling and nucleosome-depleted ‘barriers’ co-operate to determine the kinetics of nucleosome organization, in a stochastic model of nucleosome positioning and dynamics. We find that ‘statistical’ positioning of nucleosomes against ‘barrier...

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Bibliographic Details
Main Authors: Parmar, Jyotsana J., Marko, John F., Padinhateeri, Ranjith
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874171/
https://ncbi.nlm.nih.gov/pubmed/24068556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt854
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