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Transition-state stabilization in Escherichia coli ribonuclease P RNA-mediated cleavage of model substrates
We have used model substrates carrying modified nucleotides at the site immediately 5′ of the canonical RNase P cleavage site, the −1 position, to study Escherichia coli RNase P RNA-mediated cleavage. We show that the nucleobase at −1 is not essential but its presence and identity contribute to effi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3874170/ https://ncbi.nlm.nih.gov/pubmed/24097434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt853 |
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