Glutamate-induced protease-mediated loss of plasma membrane Ca(2+) pump activity in rat hippocampal neurons

Ca(2+) dysregulation is a hallmark of excitotoxicity, a process that underlies multiple neurodegenerative disorders. The plasma membrane Ca(2+) ATPase (PMCA) plays a major role in clearing Ca(2+) from the neuronal cytoplasm. Here, we show that the rate of PMCA-mediated Ca(2+) efflux from rat hippoca...

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Main Authors: Pottorf, William J., Johanns, Tanner M., Derrington, Stephen M., Strehler, Emanuel E., Enyedi, Agnes, Thayer, Stanley A.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873837/
https://ncbi.nlm.nih.gov/pubmed/16923173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2006.04063.x
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