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Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia
Poly(ADP-ribose) polymerase 1 (PARP-1) activity is detected in both neuronal and nonneuronal cells in the CNS, and excessive PARP-1 activity is known to be detrimental to tissue because of the cellular energy loss. Accordingly, PARP-1-deficient (PARP-1(-/-)) mice have been shown to be resistant to c...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2004
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC387378/ https://ncbi.nlm.nih.gov/pubmed/15041747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306895101 |
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