Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas

Simvastatin and pravastatin are inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, and are used as antihypercholesterolemia drugs. Simvastatin, but not pravastatin, binds to the inserted domain of leukocyte function antigen (LFA)-1 and inhibits the function of LFA-1, including adhesion and cost...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Katano, Harutaka, Pesnicak, Lesley, Cohen, Jeffrey I.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387356/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15041742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305149101
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