Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor

We have recently engineered an in vivo endothelial cell-specific retroviral gene transfer system and found that a single Kaposi's sarcoma (KS)-associated herpesvirus/human herpesvirus 8 gene encoding a G protein-coupled receptor (vGPCR), is sufficient to induce KS-like tumors in mice. By using...

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Main Authors: Sodhi, Akrit, Montaner, Silvia, Patel, Vyomesh, Gómez-Román, José Javier, Li, Yi, Sausville, Edward A., Sawai, Earl T., Gutkind, J. Silvio
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC387332/
https://ncbi.nlm.nih.gov/pubmed/15047889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400835101
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