Pharmacokinetic drug–drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management

BACKGROUND: Coadministration of 1,4-dihydropyridine calcium channel blockers (DHP-CCBs) with statins (or 3-hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitors) is common for patients with hypercholesterolemia and hypertension. To reduce the risk of myopathy, in 2011, the US Food and D...

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Bibliographic Details
Main Authors: Zhou, Yi-Ting, Yu, Lu-Shan, Zeng, Su, Huang, Yu-Wen, Xu, Hui-Min, Zhou, Quan
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2013
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873236/
https://ncbi.nlm.nih.gov/pubmed/24379677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/TCRM.S55512
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