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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

Hedgehog (Hh) signaling plays a major role in multiple aspects of embryonic development. A key issue in Hh signaling is to elucidate the molecular mechanism by which a Hh protein morphogen gradient is formed despite its membrane association. In this study, we used a combination of genetic, cellular,...

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Detalhes bibliográficos
Main Authors: Chen, Miao-Hsueh, Li, Ya-Jun, Kawakami, Takatoshi, Xu, Shan-Mei, Chuang, Pao-Tien
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387240/
https://ncbi.nlm.nih.gov/pubmed/15075292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1185804
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