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Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.

Transgenic mice were generated in which the cDNA for the human insulin-like growth factor 1B (IGF-1B) was placed under the control of a rat alpha-myosin heavy chain promoter. In mice heterozygous for the transgene, IGF-1B mRNA was not detectable in the fetal heart at the end of gestation, was presen...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Reiss, K, Cheng, W, Ferber, A, Kajstura, J, Li, P, Li, B, Olivetti, G, Homcy, C J, Baserga, R, Anversa, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38724/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710922/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8630
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