Cysteamine Modulates Oxidative Stress and Blocks Myofibroblast Activity in CKD

Therapy to slow the relentless expansion of interstitial extracellular matrix that leads to renal functional decline in patients with CKD is currently lacking. Because chronic kidney injury increases tissue oxidative stress, we evaluated the antifibrotic efficacy of cysteamine bitartrate, an antioxi...

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Bibliographic Details
Main Authors: Okamura, Daryl M., Bahrami, Nadia M., Ren, Shuyu, Pasichnyk, Katie, Williams, Juliana M., Gangoiti, Jon A., Lopez-Guisa, Jesus M., Yamaguchi, Ikuyo, Barshop, Bruce A., Duffield, Jeremy S., Eddy, Allison A.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2014
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871767/
https://ncbi.nlm.nih.gov/pubmed/24009239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012090962
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