Unusual N-Prenylation in Diazepinomicin Biosynthesis: The Farnesylation of a Benzodiazepine Substrate Is Catalyzed by a New Member of the ABBA Prenyltransferase Superfamily

The bacterium Micromonospora sp. RV115, isolated from a marine sponge, produces the unusual metabolite diazepinomicin, a prenylated benzodiazepine derivative. We have cloned the prenyltransferase gene dzmP from this organism, expressed it in Escherichia coli, and the resulting His(8)-tagged protein...

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Autors principals: Bonitz, Tobias, Zubeil, Florian, Grond, Stephanie, Heide, Lutz
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871700/
https://ncbi.nlm.nih.gov/pubmed/24376894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085707
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