Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function

Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, “high-risk” HPV E6 proteins bind to and modify the target specifici...

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Main Authors: Cherry, Jonathan J., Rietz, Anne, Malinkevich, Anna, Liu, Yuqi, Xie, Meng, Bartolowits, Matthew, Davisson, V. Jo, Baleja, James D., Androphy, Elliot J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871595/
https://ncbi.nlm.nih.gov/pubmed/24376816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084506
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