Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles Marfan syndrome. LDS is caused by heterozygous missense mutations in either TGF-β receptor gene (TGFBR1 or TGFBR2), wh...

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Main Authors: Gallo, Elena M., Loch, David C., Habashi, Jennifer P., Calderon, Juan F., Chen, Yichun, Bedja, Djahida, van Erp, Christel, Gerber, Elizabeth E., Parker, Sarah J., Sauls, Kimberly, Judge, Daniel P., Cooke, Sara K., Lindsay, Mark E., Rouf, Rosanne, Myers, Loretha, ap Rhys, Colette M., Kent, Kathleen C., Norris, Russell A., Huso, David L., Dietz, Harry C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871227/
https://ncbi.nlm.nih.gov/pubmed/24355923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69666
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