A Novel Immunomodulator, FTY-720 Reverses Existing Cardiac Hypertrophy and Fibrosis from Pressure Overload by Targeting NFAT Signaling and Periostin

BACKGROUND: Hypertension or aortic stenosis causes pressure overload, which evokes hypertrophic myocardial growth. Sustained cardiac hypertrophy eventually progresses to heart failure. Growing evidence indicates that restraining hypertrophy could be beneficial; here we discovered that FTY-720, an im...

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Autores principales: Liu, Wei, Zi, Min, Tsui, Hoyee, Chowdhury, Sanjoy K, Zeef, Leo, Meng, Qing-Jun, Travis, Mark, Prehar, Sukhpal, Berry, Andrew, Hanley, Neil, Neyses, Ludwig, Xiao, Rui-Ping, Oceandy, Delvac, Ke, Yunbo, Solaro, R. John, Cartwright, Elizabeth J., Lei, Ming, Wang, Xin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871200/
https://ncbi.nlm.nih.gov/pubmed/23753531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.000123
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