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Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs

Analogs of S-adenosyl-L-methionine (SAM) are increasingly applied to the methyltransferase (MT) catalysed modification of biomolecules including proteins, nucleic acids, and small molecules. However, SAM and analogs suffer from an inherent instability, and their chemical synthesis is challenged by l...

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Main Authors: Thomsen, Marie, Vogensen, Stine B., Buchardt, Jens, Burkart, Michael D., Clausen, Rasmus P.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871182/
https://ncbi.nlm.nih.gov/pubmed/24100405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob41702f
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