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Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity.

The differentiation antigen T4, present on the helper/inducer subset of T lymphocytes, is thought to serve as the receptor for the human immunodeficiency virus (HIV). We find that a 60-kDa protein, immunoprecipitable by monoclonal antibody (mAb) OKT4, is present on membranes from human brain as well...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pert, C B, Hill, J M, Ruff, M R, Berman, R M, Robey, W G, Arthur, L O, Ruscetti, F W, Farrar, W L
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1986
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387114/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3097649/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.23.9254
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