Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients

BACKGROUND: Calcium and magnesium (Ca/Mg) infusions have been suggested as an effective intervention for preventing oxaliplatin-induced neurotoxicity, but the effects of Ca/Mg infusions on oxaliplatin pharmacokinetics, motor nerve hyperexcitability and acute neurotoxicity symptoms are unclear. METHO...

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Autors principals: Han, Catherine H, Khwaounjoo, Prashannata, Kilfoyle, Dean H, Hill, Andrew, McKeage, Mark J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870994/
https://ncbi.nlm.nih.gov/pubmed/24156389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-495
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