Hypothalamic Dysfunction of the Thrombospondin Receptor α2δ-1 Underlies the Overeating and Obesity Triggered by Brain-Derived Neurotrophic Factor Deficiency

Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are critical components of the neural circuitry controlling appetite and body weight. Diminished BDNF signaling in mice results in severe hyperphagia and obesity. In humans, BDNF haploinsufficiency and the functional Bdnf Val66Met poly...

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Autori principali: Cordeira, Joshua W., Felsted, Jennifer A., Teillon, Sarah, Daftary, Shabrine, Panessiti, Micaella, Wirth, Jena, Sena-Esteves, Miguel, Rios, Maribel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870936/
https://ncbi.nlm.nih.gov/pubmed/24403154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1572-13.2014
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