MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a decrease in the efficiency of synaptic transmission at neuromuscular synapses. MG is caused by antibodies against postsynaptic proteins, including (i) acetylcholine receptors, the neurotransmitter receptor, (ii) mu...

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Detalles Bibliográficos
Main Authors: Huijbers, Maartje G., Zhang, Wei, Klooster, Rinse, Niks, Erik H., Friese, Matthew B., Straasheijm, Kirsten R., Thijssen, Peter E., Vrolijk, Hans, Plomp, Jaap J., Vogels, Pauline, Losen, Mario, Van der Maarel, Silvère M., Burden, Steven J., Verschuuren, Jan J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870730/
https://ncbi.nlm.nih.gov/pubmed/24297891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313944110
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