MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a decrease in the efficiency of synaptic transmission at neuromuscular synapses. MG is caused by antibodies against postsynaptic proteins, including (i) acetylcholine receptors, the neurotransmitter receptor, (ii) mu...

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Main Authors: Huijbers, Maartje G., Zhang, Wei, Klooster, Rinse, Niks, Erik H., Friese, Matthew B., Straasheijm, Kirsten R., Thijssen, Peter E., Vrolijk, Hans, Plomp, Jaap J., Vogels, Pauline, Losen, Mario, Van der Maarel, Silvère M., Burden, Steven J., Verschuuren, Jan J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870730/
https://ncbi.nlm.nih.gov/pubmed/24297891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313944110
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