Structural insights into the Ca(2+) and PI(4,5)P(2) binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1

Proteins containing C2 domains are the sensors for Ca(2+) and PI(4,5)P(2) in a myriad of secretory pathways. Here, the use of a free-mounting system has enabled us to capture an intermediate state of Ca(2+) binding to the C2A domain of rabphilin 3A that suggests a different mechanism of ion interact...

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Detalhes bibliográficos
Main Authors: Guillén, Jaime, Ferrer-Orta, Cristina, Buxaderas, Mònica, Pérez-Sánchez, Dolores, Guerrero-Valero, Marta, Luengo-Gil, Ginés, Pous, Joan, Guerra, Pablo, Gómez-Fernández, Juan C., Verdaguer, Nuria, Corbalán-García, Senena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870689/
https://ncbi.nlm.nih.gov/pubmed/24302762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316179110
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