MIR106B and MIR93 Prevent Removal of Bacteria from Epithelial Cells by Disrupting ATG16L1-Mediated Autophagy

BACKGROUND & AIMS: Variants in genes that regulate autophagy have been associated with Crohn’s disease (CD). Defects in autophagy-mediated removal of pathogenic microbes could contribute to pathogenesis of CD. We investigated the role of the micro-RNAs (miRs) MIR106B and MIR93 in induction of au...

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Main Authors: Lu, Changming, Chen, Jianfeng, Xu, Hua-Guo, Zhou, Xianzheng, He, Qiongqiong, Li, Yu-Lin, Jiang, Guoqing, Shan, Yuxi, Xue, Boxin, Zhao, Rui-Xun, Wang, Yong, Werle, Kaitlin D., Cui, Rutao, Liang, Jiyong, Xu, Zhi-Xiang
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870037/
https://ncbi.nlm.nih.gov/pubmed/24036151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.09.006
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