Activation of the Wnt pathway through use of AR79, a glycogen synthase kinase 3β inhibitor, promotes prostate cancer growth in soft tissue and bone

Due to its bone anabolic activity, methods to increase Wnt activity, such as inhibitors of dickkopf-1 and sclerostin, are being clinically explored. Glycogen synthase kinase (GSK3β) inhibits Wnt signaling through inducing β-catenin degradation. Therefore, AR79, an inhibitor of GSK3β, is being evalua...

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Detalhes bibliográficos
Main Authors: Jiang, Yuan, Dai, Jinlu, Zhang, Honglai, Sottnik, Joe L., Keller, Jill M., Escott, Katherine J., Sanganee, Hitesh J., Yao, Zhi, McCauley, Laurie K., Keller, Evan T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869871/
https://ncbi.nlm.nih.gov/pubmed/24088787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0332-T
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