Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.
O4-Alkylthymine-DNA adducts have been implicated as causative lesions in chemical mutagenesis and carcinogenesis. To directly assess the mutagenic potential of these adducts in vivo, we have designed an enzymatic technique for introducing nucleotide analogues at predetermined sites of biologically a...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1986
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3464967/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.22.8501 |
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