Direct sGC Activation Bypasses NO Scavenging Reactions of Intravascular Free Oxy-Hemoglobin and Limits Vasoconstriction

Aims: Hemoglobin-based oxygen carriers (HBOC) provide a potential alternative to red blood cell (RBC) transfusion. Their clinical application has been limited by adverse effects, in large part thought to be mediated by the intravascular scavenging of the vasodilator nitric oxide (NO) by cell-free pl...

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Detalhes bibliográficos
Main Authors: Raat, Nicolaas J.H., Tabima, D. Marcela, Specht, Patricia A.C., Tejero, Jesús, Champion, Hunter C., Kim-Shapiro, Daniel B., Baust, Jeff, Mik, Egbert G., Hildesheim, Mariana, Stasch, Johannes-Peter, Becker, Eva-Maria, Truebel, Hubert, Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869448/
https://ncbi.nlm.nih.gov/pubmed/23697678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5181
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