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Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine
2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methy...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3869350/ https://ncbi.nlm.nih.gov/pubmed/24367421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.292 |
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