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Mutating a Conserved Proline Residue within the Trimerization Domain Modifies Na(+) Binding to Excitatory Amino Acid Transporters and Associated Conformational Changes

Excitatory amino acid transporters (EAATs) are crucial for glutamate homeostasis in the mammalian central nervous system. They are not only secondary active glutamate transporters but also function as anion channels, and different EAATs vary considerably in glutamate transport rates and associated a...

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Detalhes bibliográficos
Main Authors: Hotzy, Jasmin, Schneider, Nicole, Kovermann, Peter, Fahlke, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868762/
https://ncbi.nlm.nih.gov/pubmed/24214974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489385
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