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Mutating a Conserved Proline Residue within the Trimerization Domain Modifies Na(+) Binding to Excitatory Amino Acid Transporters and Associated Conformational Changes
Excitatory amino acid transporters (EAATs) are crucial for glutamate homeostasis in the mammalian central nervous system. They are not only secondary active glutamate transporters but also function as anion channels, and different EAATs vary considerably in glutamate transport rates and associated a...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868762/ https://ncbi.nlm.nih.gov/pubmed/24214974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489385 |
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