IQGAP1 Protein Regulates Nuclear Localization of β-Catenin via Importin-β5 Protein in Wnt Signaling

In the canonical Wnt signaling pathway, the translocation of β-catenin is important for the activation of target genes in the nucleus. However, the molecular mechanisms underlying its nuclear localization remain unclear. In the present study, we found IQGAP1 to be a regulator of β-catenin function v...

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Bibliographic Details
Main Authors: Goto, Toshiyasu, Sato, Atsushi, Adachi, Shungo, Iemura, Shun-ichiro, Natsume, Tohru, Shibuya, Hiroshi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868749/
https://ncbi.nlm.nih.gov/pubmed/24196961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520528
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