Mevinolin, an inhibitor of cholesterol biosynthesis, drastically depresses Ca2+ channel activity and uncouples excitation from contraction in cardiac cells in culture.

Mevinolin (MK803), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (Ki, 30 X 10(-9) M), depressed de novo synthesis of cholesterol in 11-day chicken embryonic cardiac cells cultured in lipoprotein-deficient serum (LPDS). Cardiac cells exposed to different co...

Повний опис

Збережено в:

Бібліографічні деталі
Опубліковано в::	Proc Natl Acad Sci U S A
Автори:	Renaud, J F, Schmid, A, Romey, G, Nano, J L, Lazdunski, M
Формат:	Artigo
Мова:	Inglês
Опубліковано:	National Academy of Sciences 1986
Предмети:	Research Article
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386854/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2429325/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.20.8007
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!

Mevinolin, an inhibitor of cholesterol biosynthesis, drastically depresses Ca2+ channel activity and uncouples excitation from contraction in cardiac cells in culture.

Схожі ресурси