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Tau-Derived-Hexapeptide (306)VQIVYK(311) Aggregation Inhibitors: Nitrocatechol Moiety as A Pharmacophore In Drug Design
[Image: see text] The nitrocatechol derivatives tolcapone (1) and entacapone (2), used as adjunctive therapy in the treatment of Parkinson’s disease, were investigated for their potential to inhibit the tau-derived-hexapeptide (306)VQIVYK(311). They were compared to small molecules that contain simi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867965/ https://ncbi.nlm.nih.gov/pubmed/24007550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400151a |
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