Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep

Preterm brain injury is partly associated with hypoxia-ischemia starting before birth. Excessive nitric oxide production during HI may cause nitrosative stress, leading to cell membrane and mitochondrial damage. We therefore tested the hypothesis that therapy with a new, selective neuronal nitric ox...

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Hauptverfasser: Drury, Paul P., Davidson, Joanne O., van den Heuij, Lotte G., Tan, Sidhartha, Silverman, Richard B., Ji, Haitao, Blood, Arlin B., Fraser, Mhoyra, Bennet, Laura, Jan Gunn, Alistair
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867605/
https://ncbi.nlm.nih.gov/pubmed/24120436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2013.10.003
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