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Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice
Factor H-binding protein (fHbp) is a component of a meningococcal vaccine recently licensed in Europe for prevention of serogroup B disease, and a second vaccine in clinical development. The protein specifically binds human factor H (fH), which down-regulates complement activation and enhances resis...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867019/ https://ncbi.nlm.nih.gov/pubmed/24035433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2013.08.099 |
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