Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.
Signaling through the erythropoietin receptor (EPO-R) is crucial for proliferation, differentiation, and survival of erythroid progenitor cells. EPO induces homodimerization of the EPO-R, triggering activation of the receptor-associated kinase JAK2 and activation of STAT5. By mutating the eight tyro...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
1996
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710869/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8324 |
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