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Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice

BACKGROUND: The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has been indicated to have important vasculoprotective properties and to be vulnerab...

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Autors principals: Eskens, Bart JM, Zuurbier, Coert J, van Haare, Judith, Vink, Hans, van Teeffelen, Jurgen WGE
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866460/
https://ncbi.nlm.nih.gov/pubmed/24308370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-175
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