A Replicating Modified Vaccinia Tiantan Strain Expressing an Avian-Derived Influenza H5N1 Hemagglutinin Induce Broadly Neutralizing Antibodies and Cross-Clade Protective Immunity in Mice

To combat the possibility of a zoonotic H5N1 pandemic in a timely fashion, it is necessary to develop a vaccine that would confer protection against homologous and heterologous human H5N1 influenza viruses. Using a replicating modified vaccinia virus Tian Tan strain (MVTT) as a vaccine vector, we co...

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Główni autorzy: Xiao, Haixia, Liu, Li, Zhu, Qingyu, Tan, Zhiwu, Yu, Wenbo, Tang, Xian, Zhan, Dawei, Du, Yanhua, Wang, Haibo, Liu, Di, Li, Zhixin, Yuen, Kwok-Yung, Ho, David D., Gao, George F., Chen, Zhiwei
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2013
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866202/
https://ncbi.nlm.nih.gov/pubmed/24358269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083274
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