Par1b Induces Asymmetric Inheritance of Plasma Membrane Domains via LGN-Dependent Mitotic Spindle Orientation in Proliferating Hepatocytes

The development and maintenance of polarized epithelial tissue requires a tightly controlled orientation of mitotic cell division relative to the apical polarity axis. Hepatocytes display a unique polarized architecture. We demonstrate that mitotic hepatocytes asymmetrically segregate their apical p...

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Main Authors: Slim, Christiaan L., Lázaro-Diéguez, Francisco, Bijlard, Marjolein, Toussaint, Mathilda J. M., de Bruin, Alain, Du, Quansheng, Müsch, Anne, van IJzendoorn, Sven C. D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866089/
https://ncbi.nlm.nih.gov/pubmed/24358023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001739
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