A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal mice.

The nucleotide sequence of the glycoprotein genes of fully virulent Sindbis virus and derived mutants that have reduced neurovirulence for neonatal mice (attenuated mutants) has been determined. A single amino acid difference, arginine instead of serine at position 114 of the mature E2 glycoprotein,...

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Yayımlandı:	Proc Natl Acad Sci U S A
Asıl Yazarlar:	Davis, N L, Fuller, F J, Dougherty, W G, Olmsted, R A, Johnston, R E
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	National Academy of Sciences 1986
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3462725/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.18.6771
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