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Formation of a translational inhibitor by interaction of phospholipid with the eukaryotic initiation factor 2.
The polypeptide chain initiation factor 2 (eIF-2) binds phospholipid (PL) and becomes a potent inhibitor of translation in hemin-supplemented reticulocyte lysates. This binding is markedly reduced by prior treatment of eIF-2 with N-ethylmaleimide. Although PL is probably bound by all three eIF-2 sub...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1986
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3462720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.18.6711 |
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