Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer.

A retroviral vector called SAX, containing the cloned human cDNA for adenosine deaminase (ADA), has been constructed and used to introduce the ADA gene into cultured T- and B-lymphocyte lines derived from patients with ADA deficiency. DNA analysis showed that the SAX vector was inserted intact into...

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Main Authors: Kantoff, P W, Kohn, D B, Mitsuya, H, Armentano, D, Sieberg, M, Zwiebel, J A, Eglitis, M A, McLachlin, J R, Wiginton, D A, Hutton, J J
Formato: Artigo
Idioma:Inglês
Publicado: 1986
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC386544/
https://ncbi.nlm.nih.gov/pubmed/3489233
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