Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer.

A retroviral vector called SAX, containing the cloned human cDNA for adenosine deaminase (ADA), has been constructed and used to introduce the ADA gene into cultured T- and B-lymphocyte lines derived from patients with ADA deficiency. DNA analysis showed that the SAX vector was inserted intact into...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Kantoff, P W, Kohn, D B, Mitsuya, H, Armentano, D, Sieberg, M, Zwiebel, J A, Eglitis, M A, McLachlin, J R, Wiginton, D A, Hutton, J J
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1986
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386544/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3489233/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.17.6563
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