High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan

Cellular senescence of normal human cells has by now far exceeded its initial role as a model system for aging research. Many reports show the accumulation of senescent cells in vivo, their effect on their microenvironment and its double-edged role as tumour suppressor and promoter. Importantly, rem...

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Detalhes bibliográficos
Main Authors: Dellago, Hanna, Preschitz-Kammerhofer, Barbara, Terlecki-Zaniewicz, Lucia, Schreiner, Carina, Fortschegger, Klaus, Chang, Martina W-F, Hackl, Matthias, Monteforte, Rossella, Kühnel, Harald, Schosserer, Markus, Gruber, Florian, Tschachler, Erwin, Scheideler, Marcel, Grillari-Voglauer, Regina, Grillari, Johannes, Wieser, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864473/
https://ncbi.nlm.nih.gov/pubmed/23496142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12069
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