Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal.

The amino-terminal 20 amino acids are required for microinjected ribonuclease A (RNase A) to be taken up by lysosomes and degraded at an enhanced rate during serum withdrawal. We used water-soluble carbodiimides to covalently attach the RNase S-peptide (residues 1-20) to [3H]RNase S-protein (residue...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Backer, J M, Dice, J F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386389/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3526340/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.16.5830
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