Silencing PP2A Inhibitor by Lenti-shRNA Interference Ameliorates Neuropathologies and Memory Deficits in tg2576 Mice

Deficits of protein phosphatase-2A (PP2A) play a crucial role in tau hyperphosphorylation, amyloid overproduction, and synaptic suppression of Alzheimer's disease (AD), in which PP2A is inactivated by the endogenously increased inhibitory protein, namely inhibitor-2 of PP2A (I(2)(PP2A)). Theref...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Gong-Ping, Wei, Wei, Zhou, Xin, Shi, Hai-Rong, Liu, Xing-Hua, Chai, Gao-Shang, Yao, Xiu-Qing, Zhang, Jia-Yu, Peng, Cai-Xia, Hu, Juan, Li, Xia-Chun, Wang, Qun, Wang, Jian-Zhi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863796/
https://ncbi.nlm.nih.gov/pubmed/23922015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.189
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